Rapid depletion of anti-COVID antibodies may be linked to obesity, according to a new study.
According to the findings of a recently published study, there may be a connection between being overweight and the quick depletion of anti-COVID antibodies. According to the findings of the study, those who are obese may have a quicker reduction in their antibodies against COVID-19 in comparison to those who maintain a healthy weight. The purpose of this study was to assess the immune response and antibody levels of people who had previously been infected with COVID-19. According to the data, persons with obesity demonstrated a more rapid decline in their antibody levels over the course of time, which may indicate a potential sensitivity to reinfection. There is still a lot of mystery around the precise mechanism that underlies this relationship. On the other hand, there is a school of thought that suggests obesity may compromise the immune system’s capacity to generate and keep up a vigorous antibody response.
The immunological response of the body may be impacted by factors such as excess body fat and adipose tissue, both of which can play a role in the development of chronic inflammation and other metabolic dysfunctions. Although some experts were concerned that shorter needles of vaccinations would not be able to enter obese persons, this was not the case. Obesity, according to a recent frightening discovery made by experts, can also result in the loss of immunological response to viruses rather quickly, which may require recurrent injection with booster doses. After receiving their second dose of COVID, fifty-five percent of persons who are extremely obese no longer had antibodies to fight against the infection after six months had passed after their first dose. These findings were reported in the journal Nature Medicine.
On the other hand, by the same point in time, twelve percent of healthy adults had lost their protective antibodies. The experts were confused as to what was causing it, but they are investigating the possibility that hormones that are higher in fat persons are conversing with immune cells to limit the production of long-term antibodies. There were worries that shorter needles used for immunizations wouldn’t be able to pierce obese people as deeply as they needed to. However, this hypothesis was disproved when it was found that antibody levels are already high shortly after a vaccination. According to Dr. James Thaventhiran, who works at Cambridge’s Medical Research Council (MRC) Toxicology Unit, “I don’t think too short needles were a factor contributing to our findings.” Instead,
“We found that vaccine-triggered antibody levels, shortly after vaccination, were actually higher in people with obesity.”Dr. Thaventhiran further elaborated, saying that “Our data shows that waning of protection occurs more rapidly with increasing body weight.” Nobody knows why things like these keep happening. We are conducting extensive research to determine whether or if the cross-talk that occurs between immune cells and the hormones and other signaling molecules that are higher in obese individuals leads to a defect that hinders normal antibody formation. People who were obese during the COVID-19 epidemic had a greater risk of being hospitalized, requiring ventilators, and passing away as a result of the virus. The most recent study provided evidence to support the hypothesis that vaccine safety warnings were responsible for the observed association. In the research, scientists from Edinburgh
Pfizer or AstraZeneca
University monitored the health of 3.5 million people in Scotland who had received jabs from Pfizer or AstraZeneca. They discovered that people with a body mass index (BMI) greater than 40kg/m2 had a 76% higher risk of the severity of the virus as compared to those with a normal BMI. This was in comparison to those with a normal BMI. They also found that those who were extremely obese had a higher risk of developing breakthrough infections after receiving their second dosage of the vaccine, which led to an earlier risk of death. People who are obese are more likely to require booster doses on a more regular basis in order to keep their protection against COVID-19. According to Professor Sadaf Farooqi of the Wellcome-MRC Institute of Metabolic Science, “This poses a major challenge for health services due to the high prevalence of obesity across the globe.”